Fernandez Mejia, and our team care about you, the person who owns the smile, and will always treat you as family! Dental, we do more than work on teeth, relieve pain, and restore oral health and beauty. Journals: since July 2011, I have provided 212 pre-publication reviews for 57 journals including Nature, Cell Metabolism, Diabetes, and Journal of Biological Chemistry.At H.A.B. School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, UK (2016)įunding bodies: MRC, BBSRC, Wellcome Trust, Diabetes UK, Great Ormond Street Hospital Children’s Charity, The Physiological Society, Austrian Science Council, Czech Science Foundation, The Netherlands Organisation for Health Research and Development. University of Exeter Medical School, University of Exeter, UK (2017) MitOX Meeting, University of Oxford (2017) Mitochondrial biogenesis and cellular bioenergetic function in uraemic myopathyĭivision of Cell Signalling and Immunology, University of Dundee (2019)īritish Association for the Study of the Liver, Annual Basic Science Retreat (2019)ĭivision of Diabetes and Nutritional Sciences, King’s College London (2019) Research degrees awarded to supervised studentsĭr Rosie Donnell (PhD, 2022) - Nitrite and insulin lower the oxygen cost of ATP synthesis in skeletal muscle cells by pleiotropic stimulation of glycolysisĭr Jonathan Barlow (PhD, 2015) - Mitochondrial involvement in pancreatic beta cell glucolipotoxicity Grants & contracts (2015) On the mechanism by which dietary nitrate improves human skeletal muscle function. International Journal of Molecular Sciences 20, 2751.
(2019) Mitochondrial activity and skeletal muscle insulin resistance in kidney disease. (2016) Mitochondrial involvement in skeletal muscle insulin resistance - a case of imbalanced bioenergetics. (2018) Control of pancreatic beta cell bioenergetics. As detailed in the reviews listed below, my current projects focus on the bioenergetics of (1) insulin secretion by pancreatic beta cells (2) obesity-related and (3) uraemic insulin resistance of skeletal muscle, and (4) dietary-nitrate-enhanced skeletal muscle function. Defects in insulin secretion and action that arise in obesity are both features of the Metabolic Syndrome, a cluster of medical disorders that collectively increase the risk of developing type 2 diabetes. In particular, I wish to understand how mitochondrial dysfunction affects glucose-stimulated insulin secretion by pancreatic beta cells and the insulin responsiveness of skeletal muscle. Generally, I am intrigued by the role of bioenergetic failure in disease pathophysiology. University of Northampton (DPhil, 2013).La Trobe University, Melbourne, Australia (DPhil, 2018).University of East Anglia (DPhil, 2022).
My lab engages actively with undergraduate (summer, placement and dissertation projects) and postgraduate (PhD and MSc projects) students to prepare them for independent research careers. I currently teach fundamental biochemistry to undergraduates at all stages of various degree programmes and, firmly informed by my research, I show how this basic science underpins the development of metabolic disorders, and how it drives disease diagnosis and management.
To me, teaching and research are intimately linked activities, as I appreciate the importance of transferring cutting-edge knowledge and, perhaps more importantly, as I wish to inspire and enthuse the next generation of researchers.
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